Afatinib Dimaleate Intermediate CAS 314771-88-5 Purity >99.0% (HPLC) Factory

Short Description:

Chemical Name: (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine 

CAS: 314771-88-5

Purity: >99.0% (HPLC)  

Appearance: Yellow to Light Yellow Powder

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com


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Description:

Chemical Properties:

Chemical Name (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine
Synonyms N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-Amine; 7-((S)-Tetrahydrofuran-3-yloxy)-4-(3-Chloro-4-Fluorophenyl)amino-6-Nitroquinazoline; Afatinib Impurity  
CAS Number 314771-88-5
CAT Number RF-PI2027
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C18H14ClFN4O4
Molecular Weight 404.78
Density 1.534±0.060 g/cm3
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance Yellow to Light Yellow Powder
Purity / Analysis Method >99.0% (HPLC)   
Loss on Drying <0.50%
Individual Impurity <0.50%
Total Impurities <1.00%
Heavy Metals ≤20ppm
Test Standard Enterprise Standard
Usage Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

1

FAQ:

Application:

 (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine (CAS: 314771-88-5) is used in the preparation of Afatinib Dimaleate (CAS: 850140-73-7). Afatinib is an innovative anti-cancer target drug, a new generation of oral target drug, the world's first anti-cancer target drug that irreversibly binds to the ErbB family, and is more effective and targeted Blocks the signal that triggers the growth of cancer cells, reducing or delaying the proliferation of cancer cells. Afatinib belongs to a class of drugs known as tyrosine kinase inhibitors. It works by blocking the function of two closely related proteins, the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2). Used for the first-line treatment of patients with metastatic non-small cell lung cancer. Afatinib is an innovative anti-cancer target drug, a new generation of oral target drug, the world's first anti-cancer target drug that irreversibly binds to the ErbB family, and is more effective and targeted Blocks the signal that triggers the growth of cancer cells, reducing or delaying the proliferation of cancer cells.

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